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KMID : 0425120080460040261
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Parasites, Hosts and Diseases
2008 Volume.46 No. 4 p.261 ~ p.263
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A Case of Fatal Strongyloidiasis in a Patient with Chronic Lymphocytic Leukemia and Molecular Characterization of the Isolate
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Kia Eshrat Beigom
Mirhendi Hossein
Nilforoushan Mohammad Reza
Zahabiun Farzaneh
Rahimi Hamid Reza
Talebi Ardeshir
Kazemzadeh Hamid
Meamar Ahmad Reza
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Abstract
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Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment.
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KEYWORD
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Strongyloides stercoralis, hyperinfection, chronic lymphocytic leukemia, ITS1, ribosomal DNA
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