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KMID : 0425120110490010073
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Parasites, Hosts and Diseases
2011 Volume.49 No. 1 p.73 ~ p.77
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A Paragonimiasis Patient with Allergic Reaction to Praziquantel and Resistance to Triclabendazole: Successful Treatment after Desensitization to Praziquantel
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Kyung Sun-Young
Cho Yong-Kyun
Kim Yu-Jin
Park Jeong-Woong
Jeong Sung-Hwan
Lee Jae-Ik
Sung Yon-Mi
Lee Sang-Pyo
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Abstract
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Paragonimiasis is an infectious disease caused by trematodes of the genus Paragonimus. This trematode can be treated successfully with praziquantel in more than 90% of the cases. Although praziquantel is generally well tolerated, anaphylactic reactions to this drug have been reported in a few cases. We report here a 46-year-old Korean female with paragonimiasis, presumed to be due to Paragonimus westermani, who displayed an allergic reaction to praziquantel and resistance to triclabendazole treatment. The patient was successfully treated with praziquantel following a rapid desensitization procedure. Desensitization to praziquantel could be considered when no alternative drugs are available.
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KEYWORD
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Paragonimus, paragonimiasis, praziquantel, triclabendazole, drug allergy, desensitization
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