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KMID : 0425120110490030235
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Parasites, Hosts and Diseases
2011 Volume.49 No. 3 p.235 ~ p.243
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Protease-Activated Receptor 2 Is Involved in Th2 Responses against Trichinella spiralis Infection
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Park Mi-Kyung
Cho Min-Kyoung
Kang Shin-Ae
Park Hye-Kyung
Kim Yun-Seong
Kim Ki-Uk
Ahn Soon-Cheol
Kim Dong-Hee
Yu Hak-Sun
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Abstract
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In order to get a better understanding of the role of protease-activated receptor 2 (PAR2) in type 2 helper T (Th2) cell responses against Trichinella spiralis infection, we analyzed Th2 responses in T. spiralis-infected PAR2 knockout (KO) mice. The levels of the Th2 cell-secreted cytokines, IL-4, IL-5, and IL-13 were markedly reduced in the PAR2 KO mice as compared to the wild type mice following infection with T. spiralis. The serum levels of parasite-specific IgE increased significantly in the wild type mice as the result of T. spiralis infection, but this level was not significantly increased in PAR2 KO mice. The expression level of thymic stromal lymphopoietin, IL-25, and eotaxin gene (the genes were recently known as Th2 response initiators) of mouse intestinal epithelial cells were increased as the result of treatment with T. spiralis excretory-secretory proteins. However, the expression of these chemokine genes was inhibited by protease inhibitor treatments. In conclusion, PAR2 might involve in Th2 responses against T. spiralis infection.
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KEYWORD
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Trichinella spiralis, protease-activated receptor 2, IL-25, thymic stromal lymphopoietin (TSLP)
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