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KMID : 0425120120500030229
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Parasites, Hosts and Diseases
2012 Volume.50 No. 3 p.229 ~ p.231
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Detection of Ocular Toxoplasma gondii Infection in Chronic Irregular Recurrent Uveitis by PCR
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Lee Sang-Eun
Jeong Young-Il
Kim Sun-Hyun
Lee Won-Ja
Hong Sung-Hee
Lee Seong-Ho
Lim Su-Jin
Kwon Oh-Woong
You Young-Sung
Cho Shin-Hyeong
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Abstract
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Toxoplasma gondii is a zoonotic parasite resulting in human infections and one of the infectious pathogens leading to uveitis and retinochoroiditis. The present study was performed to assess T. gondii infection in 20 ocular patients with chronic irregular recurrent uveitis (20 aqueous humor and 20 peripheral blood samples) using PCR. All samples were analyzed by nested PCR targeting a specific B1 gene of T. gondii. The PCR-positive rate was 25% (5/20), including 5% (1) in blood samples, 25% (5) in aqueous humor samples, and 5% (1) in both sample types. A molecular screening test for T. gondii infection in ocular patients with common clinical findings of an unclear retinal margin and an inflammatory membrane over the retina, as seen by fundus examination, may be helpful for early diagnosis and treatment.
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KEYWORD
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Toxoplasma gondii, toxoplasmosis, uveitis, nested PCR, B1 gene
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