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KMID : 0425120130510050583
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Parasites, Hosts and Diseases
2013 Volume.51 No. 5 p.583 ~ p.588
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Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice
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Kang Shin-Ae
Park Mi-Kyung
Cho Min-Kyoung
Yu Hak-Sun
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Abstract
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To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-α) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice.
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KEYWORD
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Toxascaris leonina, visceral larva migrans (VLM), Th1, Th2, Th17, cytokine
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