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KMID : 0425120140520050501
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Parasites, Hosts and Diseases
2014 Volume.52 No. 5 p.501 ~ p.505
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Evaluation of the Accuracy of the EasyTest™ Malaria Pf/Pan Ag, a Rapid Diagnostic Test, in Uganda
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Chong Chom-Kyu
Cho Pyo-Yun
Na Byoung-Kuk
Ahn Seong-Kyu
Kim Jin-Su
Lee Jin-Soo
Lee Sung-Keun
Han Eun-Taek
Kim Hak-Yong
Park Yun-Kyu
Cha Seok-Ho
Kim Tong-Soo
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Abstract
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In recent years, rapid diagnostic tests (RDTs) have been widely used for malaria detection, primarily because of their simple operation, fast results, and straightforward interpretation. The Asan EasyTest™ Malaria Pf/Pan Ag is one of the most commonly used malaria RDTs in several countries, including Korea and India. In this study, we tested the diagnostic performance of this RDT in Uganda to evaluate its usefulness for field diagnosis of malaria in this country. Microscopic and PCR analyses, and the Asan EasyTest™ Malaria Pf/Pan Ag rapid diagnostic test, were performed on blood samples from 185 individuals with suspected malaria in several villages in Uganda. Compared to the microscopic analysis, the sensitivity of the RDT to detect malaria infection was 95.8% and 83.3% for Plasmodium falciparum and non-P. falciparum, respectively. Although the diagnostic sensitivity of the RDT decreased when parasitemia was ≤500 parasites/μl, it showed 96.8% sensitivity (98.4% for P. falciparum and 93.8% for non-P. falciparum) in blood samples with parasitemia ≥100 parasites/μl. The specificity of the RDT was 97.3% for P. falciparum and 97.3% for non-P. falciparum. These results collectively suggest that the accuracy of the Asan EasyTest™ Malaria Pf/Pan Ag makes it an effective point-of-care diagnostic tool for malaria in Uganda.
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KEYWORD
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Plasmodium falciparum, rapid diagnostic test, malaria, point-of-care testing, field test, Uganda
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