|
KMID : 0425120150530010001
|
|
Parasites, Hosts and Diseases
2015 Volume.53 No. 1 p.1 ~ p.11
|
|
|
Serine Proteases of Parasitic Helminths
|
|
Yang Yong
Wen Yun jun
Cai Ya Nan
Vallee Isabelle
Boireau Pascal
Liu Ming Yuan
Cheng Shi Peng
|
|
|
Abstract
|
|
|
|
Serine proteases form one of the most important families of enzymes and perform significant functions in a broad range of biological processes, such as intra- and extracellular protein metabolism, digestion, blood coagulation, regulation of development, and fertilization. A number of serine proteases have been identified in parasitic helminths that have putative roles in parasite development and nutrition, host tissues and cell invasion, anticoagulation, and immune evasion. In this review, we described the serine proteases that have been identified in parasitic helminths, including nematodes (Trichinella spiralis, T. pseudospiralis, Trichuris muris, Anisakis simplex, Ascaris suum, Onchocerca volvulus, O. lienalis, Brugia malayi, Ancylostoma caninum, and Steinernema carpocapsae), cestodes (Spirometra mansoni, Echinococcus granulosus, and Schistocephalus solidus), and trematodes (Fasciola hepatica, F. gigantica, and Schistosoma mansoni). Moreover, the possible biological functions of these serine proteases in the endogenous biological phenomena of these parasites and in the host-parasite interaction were also discussed.
|
|
|
KEYWORD
|
|
|
Serine protease, biological function, parasitic helminth, nematode, trematode, cestode
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|
|