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KMID : 0425120150530010129
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Parasites, Hosts and Diseases
2015 Volume.53 No. 1 p.129 ~ p.134
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High Genetic Variability of Schistosoma haematobium in Mali and Nigeria
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Ezeh Charles
Yin Mingbo
Li Hongyan
Zhang Ting
Xu Bin
Sacko Moussa
Feng Zheng
Hu Wei
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Abstract
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Schistosoma haematobium is one of the most prevalent parasitic flatworms, infecting over 112 million people in Africa. However, little is known about the genetic diversity of natural S. haematobium populations from the human host because of the inaccessible location of adult worms in the host. We used 4 microsatellite loci to genotype individually pooled S. haematobium eggs directly from each patient sampled at 4 endemic locations in Africa. We found that the average allele number of individuals from Mali was significantly higher than that from Nigeria. In addition, no significant difference in allelic composition was detected among the populations within Nigeria; however, the allelic composition was significantly different between Mali and Nigeria populations. This study demonstrated a high level of genetic variability of S. haematobium in the populations from Mali and Nigeria, the 2 major African endemic countries, suggesting that geographical population differentiation may occur in the regions.
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KEYWORD
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Schistosoma haematobium, allelic diversity, allelic composition, microsatellite, Mali, Nigeria
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