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KMID : 0425120160540020201
Parasites, Hosts and Diseases
2016 Volume.54 No. 2 p.201 ~ p.204
High Toxoplasma gondii Seropositivity among Brain Tumor Patients in Korea
Jung Bong-Kwang

Song Hye-Mi
Kim Min-Jae
Cho Jae-Eun
Shin Eun-Hee
Chai Jong-Yil
Abstract
Toxoplasma gondii is an intracellular protozoan that can modulate the environment of the infected host. An unfavorable environment modulated by T. gondii in the brain includes tumor microenvironment. Literature has suggested that T. gondii infection is associated with development of brain tumors. However, in Korea, epidemiological data regarding this correlation have been scarce. In this study, in order to investigate the relationship between T. gondii infection and brain tumor development, we investigated the seroprevalence of T. gondii among 93 confirmed brain tumor patients (various histological types, including meningioma and astrocytoma) in Korea using ELISA. The results revealed that T. gondii seropositivity among brain tumor patients (18.3%) was significantly (P<0.05) higher compared with that of healthy controls (8.6%). The seropositivity of brain tumor patients showed a significant age-tendency, i.e., higher in younger age group, compared with age-matched healthy controls (P<0.05). In conclusion, this study supports the close relationship between T. gondii infection and incidence of brain tumors.
KEYWORD
Toxoplasma gondii, seroprevalence, brain tumor, ELISA
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SCI(E) MEDLINE ÇмúÁøÈïÀç´Ü(KCI) KoreaMed ´ëÇÑÀÇÇÐȸ ȸ¿ø