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KMID : 0425120190570030249
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Parasites, Hosts and Diseases
2019 Volume.57 No. 3 p.249 ~ p.256
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Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection
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Tsai Hung-Chin
Chen Yu-Hsin
Yen Chuan-Min
Chung Li-Yu
Wann Shue-Ren
Lee Susan Shin-Jung
Chen Yao-Shen
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Abstract
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Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexamethasone-treated group. Expression of 14-3-3 β, γ, ε, and θ isoforms increased in brain meninges over the 3-week period after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.
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KEYWORD
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Angiostrongylus cantonensis, dexamethasone, eosinophile, meningitis, 14-3-3 isoform
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