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KMID : 0425120200580020161
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Parasites, Hosts and Diseases
2020 Volume.58 No. 2 p.161 ~ p.171
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Changes in Protein Phosphorylation during Salivary Gland Degeneration in Haemaphysalis longicornis
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Xiao Qi
Hu Yuhong
Yang Xiaohong
Tang Jianna
Wang Xiaoshuang
Xue Xiaomin
Li Mengxue
Wang Minjing
Zhao Yinan
Liu Jingze
Wang Hui
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Abstract
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The ticks feed large amount of blood from their hosts and transmit pathogens to the victims. The salivary gland plays an important role in the blood feeding. When the female ticks are near engorgement, the salivary gland gradually loses its functions and begins to rapidly degenerate. In this study, data-independent acquisition quantitative proteomics was used to study changes in the phosphorylation modification of proteins during salivary gland degeneration in Haemaphysalis longicornis. In this quantitative study, 400 phosphorylated proteins and 850 phosphorylation modification sites were identified. Trough RNA interference experiments, we found that among the proteins with changes in phosphorylation, apoptosis-promoting Hippo protein played a role in salivary gland degeneration.
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KEYWORD
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Tick, salivary gland, apoptosis, data-independent acquisition, RNA interference, Hippo
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