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KMID : 0425120200580040413
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Parasites, Hosts and Diseases
2020 Volume.58 No. 4 p.413 ~ p.419
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Prevalence of Toxocariasis and Its Risk Factors in Patients with Eosinophilia in Korea
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Song Hyun-Beom
Lee Deok-Ho
Jin Yan
Kang Jin-Woo
Cho Shin-Hyeong
Park Min-Sun
Park Jin-Ho
Song Woo-Jung
Kang Hye-Ryun
Lee Sang-Hyub
Hong Sung-Tae
Choi Min-Ho
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Abstract
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Eosinophilia occurs commonly in many diseases including allergic diseases and helminthic infections. Toxocariasis has been suggested as one cause of eosinophilia. The present study was undertaken to examine the prevalence of toxocariasis in patients with eosinophilia and to identify the risk factors for toxocariasis. This prospective cohort study recruited a total of 81 patients with eosinophilia (34 males and 47 females) who visited the outpatient clinic at Seoul National University Hospital from January 2017 to February 2018 and agreed to participate in this study. The prevalence of toxocariasis was examined by T. canis-specific ELISA, and the various risk factors for toxocariasis were evaluated by a questionnaire survey. Among 81 patients with eosinophilia, 18 were positive for anti-T. canis antibodies (22.2%); 88.9% were male (16/18) and 11.1% were female (2/18). Multivariate statistical analysis revealed that males (OR 21.876, 95% CI: 1.667?287.144) with a history of consuming the raw meat or livers of animals (OR 5.899, 95% CI: 1.004?34.669) and a heavy alcohol-drinking habit (OR 8.767, 95% CI: 1.018?75.497) were at higher risk of toxocariasis in patients with eosinophilia. Toxocariasis should be considered a potential cause of eosinophilia when the patient has a history of eating the raw meat or livers of animals in Korea. A single course of albendazole is recommended to reduce the migration of Toxocara larvae in serologically positive cases with eosinophilia.
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KEYWORD
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Toxocara canis, toxocariasis, eosinophilia, risk factor, raw meat, raw liver
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