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KMID : 0425120210590030297
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Parasites, Hosts and Diseases
2021 Volume.59 No. 3 p.297 ~ p.301
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Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo
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Zhang Run-Hui
Jin Runhao
Deng Hao
Shen Qing-Kun
Quan Zhe-Shan
Jin Chun-Mei
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Abstract
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Toxoplasma gondii infection is widespread worldwide, not only posing a serious threat to human food safety and animal husbandry, but also endangering human health. The selectivity index was employed to measure anti-T. gondii activity. Hederagenin (HE) exhibited potent anti-T. gondii activity and low cytotoxicity. For this reason, HE was selected for in vivo experiments. HE showed 64.8%±13.1% inhibition for peritoneal tachyzoites in mice, higher than spiramycin 56.8%±6.0%. Biochemical parameters such as alanine aminotransferase, aspartate aminotransferase, glutathione, and malondialdehyde, illustrated that HE was a good inhibitor of T. gondii in vivo. This compound was also effective in relieving T. gondii-induced liver damage. Collectively, it was demonstrated that HE had potential as an anti-T. gondii agent.
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KEYWORD
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Toxoplasma gondii, hederagenin, inhibition, in vitro, in vivo
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