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KMID : 0425120210590050439
Parasites, Hosts and Diseases
2021 Volume.59 No. 5 p.439 ~ p.445
Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrix
Kim Woo-Hyun

Min Won-Gi
Park Kwang-Il
Lillehoj Hyun S.
Fernandez-Colorado Cherry P.
Flores Rochelle A.
Cammayo Paula Leona T.
Nguyen Binh Thanh
Abstract
Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. Therefore, this study aims to investigate the expression of cNK-lysin in E. necatrix-infected chickens and its role in E. necatrix infection. The expression of cNK-lysin transcript was significantly increased in E. necatrix sporozoites-treated lymphocytes. In E. necatrix infection, cNK-lysin transcript was induced in intestinal lymphocytes but not in the spleen. The recombinant cNK-lysin exhibited anticoccidial activity against E. necatrix sporozoites as well as immunomodulatory activity on macrophages by inducing proinflammatory cytokines. These results indicated that E. necatrix infection induces high local expression of cNK-lysin and the secreted cNK-lysin helps protect coccidiosis.
KEYWORD
Eimeria necatrix, chicken, NK-lysin, antimicrobial peptide, coccidiosis
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