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KMID : 0425120230610010024
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Parasites, Hosts and Diseases
2023 Volume.61 No. 1 p.24 ~ p.32
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Genetic diversity of Plasmodium falciparum erythrocyte membrane protein 1 in field isolates from central Myanmar
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Dinzouna-Boutamba Sylvatrie-Danne
Lee Sang-Hyun
Moon Zin
Chung Dong-Il
Hong Yeon-Chul
Myint Moe Kyaw
Naw Haung
Na Byoung-Kuk
Goo Youn-Kyoung
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Abstract
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Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the polymorphic var multigene family, is a highly polymorphic antigen that plays a crucial role in the pathology of malaria. The contribution of the genetic diversity of var toward the immune escape of P. falciparum has not yet been fully elucidated. This study aimed to characterize the diversity of var repertoires by screening P. falciparum Duffy-binding-like α domain (PfDBLα) among field isolates from central Myanmar. Genetic analysis revealed that the D-H segments of var in Myanmar populations have an extensive polymorphic repertoire, with high numbers of unique sequence types in each individual. However, var genes from the global population, including Myanmar, shared close genetic lineages regardless of their geographic origins, indicating that they have not undergone rapid evolutionary changes.
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KEYWORD
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Plasmodium falciparum, erythrocyte membrane protein 1, genetic diversity, Myanmar
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