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KMID : 0425120230610030282
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Parasites, Hosts and Diseases
2023 Volume.61 No. 3 p.282 ~ p.291
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Evaluating the activity of N-89 as an oral antimalarial drug
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Nagwa S. M. Aly
Hiroaki Matsumori
Thi Quyen Dinh
Akira Sato
Shin-ichi Miyoshi
Chang Kyung-Soo
Yu Hak- Sun
Takaaki Kubota
Yuji Kurosaki
Duc Tuan Cao
Gehan A. Rashed
Kim Hye-Sook
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Abstract
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Despite the recent progress in public health measures, malaria remains a troublesome disease that needs to be eradicated. It is essential to develop new antimalarial medications that are reliable and secure. This report evaluated the pharmacokinetics and antimalarial activity of 1,2,6,7-tetraoxaspiro[7.11]nonadecane (N-89) using the rodent malaria parasite Plasmodium berghei in vivo. After a single oral dose (75 mg /kg) of N-89, its pharmacokinetic parameters were measured, and t1/2 was 0.97 h, Tmax was 0.75 h, and bioavailability was 7.01%. A plasma concentration of 8.1 ng/ml of N-89 was maintained for 8 h but could not be detected at 10 h. The dose inhibiting 50% of parasite growth (ED50) and ED90 values of oral N-89 obtained following a 4-day suppressive test were 20 and 40 mg/kg, respectively. Based on the plasma concentration of N-89, we evaluated the antimalarial activity and cure effects of oral N-89 at a dose of 75 mg/kg 3 times daily for 3 consecutive days in mice harboring more than 0.5% parasitemia. In all the N-89- treated groups, the parasites were eliminated on day 5 post-treatment, and all mice recovered without a parasite recurrence for 30 days. Additionally, administering oral N-89 at a low dose of 50 mg/kg was sufficient to cure mice from day 6 without parasite recurrence. This work was the first to investigate the pharmacokinetic char-acteristics and antimalarial activity of N-89 as an oral drug. In the future, the following steps should be focused on developing N-89 for malaria treatments; its administration schedule and metabolic pathways should be investigated.
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KEYWORD
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New antimalarial candidate, oral N-89, pharmacokinetics, in vivo
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