KMID : 0545120090190060556
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Journal of Microbiology and Biotechnology 2009 Volume.19 No. 6 p.556 ~ p.559
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NF-¥êB Activation by Compounds Found in Platycodon grandiflorum Extract
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Hong Sung-Won
Yong Yeon-Joong Kang Kyung-Rai Shin Soon-Young Lee Young-Han Lim Yoong-Ho
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Abstract
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Compounds extracted from Platycodon grandiflorum were evaluated for an activation effect on nuclear factor-kappa B (NF-¥êB). In its active state, NF-¥êB turns on the expression of genes related to cell proliferation or death. NF-¥êB activators promote growth of neuron cells and can be used to control neurodegenerative diseases. The biological activity of P. grandiflorum extracts toward NF-¥êB had not yet been studied. Although the biological activity of several compounds extracted from P. grandiflorum was evaluated, only three exhibited any significant activation effect on NF-¥êB.
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KEYWORD
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Platycodon grandiflorum, lobetyol, lobetyolin, NF-¥êB
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