|
KMID : 0578319910010020169
|
|
Molecules and Cells
1991 Volume.1 No. 2 p.169 ~ p.175
|
|
|
Differential Effects of Ferritin of the Humoral and Cullular Immune Responses in the Mouse
|
|
Chung, Hun-Taeg
Jang, Seol-Il/Song, Ho Yeing/Youn, Myung-Ja/Lee, Geum=Young
|
|
|
Abstract
|
|
|
|
Ferritin was utilized to elucidate the role of iron metabolism in defense mechanism. The intraperitoneal administration of ferritin suppressed contact hypersensitivity (CH) and delayed-type hypersensitivity (DTH) in a mouse when CH and DTH were induced by dinitrofluorobenzene (DNFB) and sheep red blood cells (SRBC) as antigens, respectively. The level of immune suppression differed significantly in accordance to the dose of ferritin and the elapsed time after ferritin administration. When ferritin was administered one day before challenge, it resulted in 75-80% reduction of CH at the dose of 1 mg, and 50% reduction at the dose of 0.12 mg. There was 70% reduction of CH when ferritin was introduced at challenge at the dose of´ 1 mg. DTH was also significantly affected by ferritin injection. However, serum anti-SRBC antibody titer was not affected by ferritin at all. The suppressive effect of ferritin on the cellular immune response was completely reversed by the cycloxygenase inhibitor of arachidonic acid metabolism, indomethacin. The results indicate that ferritin suppresses only the cellular immune response by affectithe efferent phase.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|