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KMID : 0578319910010030351
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Molecules and Cells
1991 Volume.1 No. 3 p.351 ~ p.355
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Exon/intron Sequence of the Murine T Cell Receptor Constant (Cβ1) Gene
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Sohn Uik
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Abstract
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Germline DNA clones containing the constant genes (CR1 and CO2) coding for the 0 chain of the mouse T-cell receptor were isolated and nucleotide sequence of the CR1 gene was determined. The two constant (C}region gene segments are almost identical over their entire coding region and splice junction sequences. Comparison of the mouse Col gene with the human counterpart reveals more than 80% sequence homologies in their coding regions and exon/intron boundaries. Both genes are arranged in four exons, interrupted by introns at the same positions.
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