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KMID : 0578319910010040491
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Molecules and Cells
1991 Volume.1 No. 4 p.491 ~ p.496
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Screening of a Specific Point Mutation in Tumor Suppressor p53 gene of Korean Hepatocellular Carcinoma Tissues
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Lee, Bok-Soo
Jun, Chang-Duk/Chun, Young-Whan/Paik, Sang-Gi/Cho, Baik-Whan/Choi, Chan/Chae, Kwon-Mook
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Abstract
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The point mutation at a specific site (the third base of codon 249 of exon 7) in the p53 gene was not found in the 8 hepatocellular carcinoma samples from Korean patients. This result is quite different from the report on Chinese and South African patients that showed the point mutations at the same site with the frequency of 501/o in hepatocellular carcinoma sample. Even though this particular point mutation was not found in Korean samples, there might be mutations at other sites of p53 gene, because expression of mutated p53 gene was detected in the nuclei of hepatocellular carcinoma samples by using mono-clonal antibodies which are specific for mutant-type p53 proteins. Also the change of DNA content was found in the hepatocellular carcinoma samples.
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KEYWORD
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