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KMID : 0578319920020010001
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Molecules and Cells
1992 Volume.2 No. 1 p.1 ~ p.5
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The Arg-Gly-Asp Sequence Motif Conserved in Capsid Protein VP1 of Coxsackievirus A9 Strains
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Chang Ki-Ha
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Abstract
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The complete nucleotide sequence of coxsackievirus A9 has been previously determined [Chang et al. (1989) J. Gen. Krol. 70, 3269-32801. The sequence is distinguished from those of other enteroviruses by the presence of a C-terminal extention to the capsid protein VP1. This extension contains an RGD (arginine-glycine-aspartic acid) sequence motif which is found at the receptor attachment site of many proteins. Five wild type coxsackievirus A9 strains in the region of extensions have been sequenced using polymerase chain reaction. All the sequences contain the RGD sequence, although the region flanking the motif is variable. This implies that the RGD is critical to the virus, presumably at the receptor attachment level.
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