|
KMID : 0578319920020030297
|
|
Molecules and Cells
1992 Volume.2 No. 3 p.297 ~ p.302
|
|
|
Promoter Sequence of Soybean Glycinin Gene regulates Seed-specific Expression in Transgenic Tobacco Plant
|
|
Park, Jee Won
Kim, Chung Ho/Kang, Hong-Gu/Choi, Yang Do
|
|
|
Abstract
|
|
|
Aromatic hydrocarbon nuclear translocator (Arnt) is an ubiquitously expressed protein that contains basic helix-loop-helix (bHLH) and Per-AhR-Arnt-Sim (PAS) motifs.
Other bHLH-PAS proteins, hypoxia-inducible factor-1α(HIF-1α) and dioxin-signal pathway, respectively.
Arnt has been identified as a heterodime-rization partner for AhR.
AhR/Arnt heterodimer binds the regulatory region of xenobiotic-induced genes and activates their transcription.
Here, in vivo results provide evidence that Arnt is involved in not only xenobiotic- but also hypoxia-induced transcriptional activation.
In hypoxic condition, Arnt dimerizes with HIF-1α/Arnt hetero dimer functions as a transactivator for hypoxia-inducible genes.
Given that the expression of Arnt is limired, HIF-1α may compete with AhR for recruiting Arnt as a heteromeric partner.
Consistent with this idea, the results indicate that the hypoxic activation of HIF-1α reduces dioxin-induced AhR´s function on the dioxin-responsive reporter gene and the endogenous gene.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|