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KMID : 0578319930030010035
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Molecules and Cells
1993 Volume.3 No. 1 p.35 ~ p.41
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EGF Stimulates invasive Transition of Non-invasive SCC13 Cells Accompanied by Increases in Type I Collegenase and Basal Cell Population
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Son Youngsook
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Abstract
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Possible role of epidermal growth factor (EGF) in invasive transition of squamous cell carcinoma (SCC) was investigated in raft culture of SCC13 cell line grown in the presence of various concentrations of EGF. EGF at 15-30 ng/ml stimulated stationary SCC13 cells to invade into collagen matrix and increased basal cell population within the architecture of SCC13 raft culture. This invading event was characterized with increase in basal cell population, which was confirmed by proliferation competence and expression of basal cell marker proteins such as fibronectin receptor and keratin 5/keratin 14. Specific induction in type 1 collagenase was also demonstrated by SCC13 cells upon treatment of EGF and its induction was in a concentration dependent manner to EGF. Collagen degradation by type 1 collagenase and concomittent elevation in basal population may facilitate non-invasive SCC13 cells to invade into collagen matrix.
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