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KMID : 0578319940040010057
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Molecules and Cells
1994 Volume.4 No. 1 p.57 ~ p.61
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The Effect of albumin on GPC Metabolism in Swiss 3T3, 3T3-H.ras, and HepG2 Cells
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Hong Seong-Tschool
Park Kie-In
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Abstract
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The effect of albumin on glycerophosphocholine (GPC) metabolism in HepG2, swiss 3T3, and 3T3-H ras cells prelabelled with [Me-´H]chohne was studied. The [´H]choline was most actively taken up by the 3T3-H.ras cells and least taken up by the 3T3 cells. The 313-H.ras cells showed an unusual high incorporation of [´H]chohne into [´H]GPC and HepG2 cells showed an even higher incorporation of [´H]choline into [1H]GPC than did the 313 cells. It is concluded that the tumorous cells (3T3-Kral and HepG2) more actively converted the choline derived lipid metabolite into GPC then nontumorous cells (3T3 and rat hepatocytes). Albumin simulated the [´H]GPC release into medium in all of the three cell fines possibly by the cationic ligand complexing properties of the protein.
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