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KMID : 0578319940040010085
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Molecules and Cells
1994 Volume.4 No. 1 p.85 ~ p.90
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Types of Nucleolar hepertrophy in Rat Liver
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Jeong, Jin Sook
Kang, Hong Ja/Lee, Hye Jeong/Choi, Yong Chun
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Abstract
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The mechanism of nucleolar hypertrophy was investigated in various hypertrophogenic conditions of rat liver. Induction of nucleolar enlargement was made by partial hepatectomy, thioacetamide treatment or partial hepatectomy after thioacetamide treatment. In those experimental conditions, the nucleolar structures were characterized by staining technology for morphology and also by immunological analysis for molecular characterization. Based on the immunological studies using a proliferative antigen p120, the nucleolar hypertrophy could be classified into the proliferative hypertrophy type and the non-proliferative type. The most prominent enlargement was observed in the thioacetamide treated hepatocytes where B23 increased at the highest levels among other nucleolar proteins.
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