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KMID : 0578319940040040487
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Molecules and Cells
1994 Volume.4 No. 4 p.487 ~ p.494
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The Variable Number of Tandem Repeats Allele Distribution in the Korean population (Ⅰ)
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Kim, Soo-Hyoung
Kim, Dae-Wham/Chung, Yeon-Bo
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Abstract
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The variable number of tandem repeats (VNTR) revolutionized human identity testing by their large number of alleles and easy detectability. A few VNTR loci examined together can give an allele combination which no two persons can share unless they are identical twins. The DNA test is dependent on the frequency of alleles in a population. We investigated the allele frequency at three popular VNTR loci , D2S44, D10S28 and D17S26, with over three hundred Korean subjects. To have a conservative estimation of the allele-frequency, the alleles were classified into 30 bins which are demarcated by the more or less evenly spaced molecular weight markers. Although it is not possible to assess the equilibrium state of the alleles at these VNTR loci, the application of the Hardy-Weinberg test showed that the observed number of homozygotes of binned alleles were in agreement with the expected numbers. The cumulative power of exclusion of these three RFLP VNTRs was 0.990. Together with the study on the four VNTRs based on PCR in the accompanying paper, the allele distribution in these VNTR loci will provide an unequivocal basis to distinguish any two Koreans by DNA profiles.
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