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KMID : 0578319950050030191
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Molecules and Cells
1995 Volume.5 No. 3 p.191 ~ p.195
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Cell Cycle-Dependent Phosphorylation of the tumor supperssor RB Protein
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Tay, Yoichi
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Abstract
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Cell cyclr-dependent phosphorylation of the RB protein plays a key role in the regulation of cellular proliferation. At least three kinds of cyclin-dependent kinases (Cdks), including cyclin D/Cdk6 or Cdk4, cyclin E/Cdk2 and cyclin A/Cdk2, are involved in the phosphorylation of the RB protein at G1/S border. These Gl cyclin/Cdks seem to be the focal target of carcinogenesis signals. Multistep carcinogenesis could be also explained based on this hypothesis. Thus, Gl cyclin/Cdks are good target for discovery of anti-cancer drugs.
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KEYWORD
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