KMID : 0578319950050050481
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Molecules and Cells 1995 Volume.5 No. 5 p.481 ~ p.485
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Association between Genetic Variation of the Lipoprotein Lipase Gene and Combined Hyperlipidemia
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Hong, Seung-Ho
kang, Byung-Yong/Park, Woo-Hyun/Lee, Chung-Choo/Kim, Jin Q
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Abstract
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In view of the effects of lipoprotein lipase (LPL) on plasma lipid levels, we have analysed the association between LPL polymorphism and lipid levels in the combined hyperlipidemic subjects. The allele frequency of the Pvu¥±polymorphic site showed a significant difference between control and combined hyperlipidemic groups (P<0.005). But there was no significant difference in the allele frequency of the Hind¥² polymorphic site. Each polymorphic site had values of relatively high heterozygosity and polymorphism information content (PIC). The P1P1 genotype of the Pvu¥±site was associated with elevated triglyceride levels in combined hyperlipidemic group. Subjects with a heterozygous genotype had intermediate levels of triglyceride. Thus, Pvu¥± polymorphism indicated a gene dosage effect on the triglyceride levels in the combined hyperlipidemic group. Compared to the Pvu¥± site, the Hind¥² site showed little association with lipid levels. The effects of LPL polymorphism on lipid profiles varies significantly among racial or ethnic groups. So we have discussed the clinical importance of these RFLPs.
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KEYWORD
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