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KMID : 0578319960060020197
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Molecules and Cells
1996 Volume.6 No. 2 p.197 ~ p.202
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Cooperative Transcriptional Activation by Two Glutamine-rich Regions of twist Product in Drosophila melanogaster
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Chung, Ki Wha
Lee, Young Mi/Park, Tae Kyu/Kim, Se Jae/Lee, Chung Choo
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Abstract
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twist is one of the important genes that determine dorsa l-ventral (D-V) axis during embryogenesis in Drosophila. The twist which is expressed in the ventral part of an embryo encodes a transcription factor which contains a basic helix-loop-helix (bHLH) domain. Twist (twist product) has two distinct glutamine-rich regions (QRs) on the upstream of the bHLH domain (major QR: QR-A, minor QR: QR-B). Domain analysis on the QRs using modified yeast two-hybrid assay has revealed that the QR-A has the function of a transcriptional activation domain. Although the QR-A alone could play the role of transcriptional activation domain, the QR-B may be required for stronger transcriptional activation.
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