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KMID : 0578319970070020204
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Molecules and Cells
1997 Volume.7 No. 2 p.204 ~ p.207
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Sequence Analysis, Tissue Expression and Chromosomal Localization of a Mouse Secreted Superoxide Dismutase Gene
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Suh, Jun-Gyo
Takai, Setsuo/Yamanishi, Toshiyuki/Kikuchi, Tateki/Folz, rodney J./Tanaka, Kohichi/Oh, Ynag-Seok
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Abstract
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Using a reverse transcriptase polymerase chain reaction (RT-PCR), a complement DNA encoding secreted superoxide dismutase (s-SOD) of a mouse kidney has been isolated and the nucleotide sequence was determined. The deduced amino acid sequence of mouse s-SOD cDNA shares 79% identity with the rat seminal SOD sequence and 61% identity with the human SOD3 sequence. Northern blot analysis showed that mouse s-SOD is intensely expressed in the kidney and lung tissues and detectable in other tested tissues, including the brain. The mouse s-SOD gene was assigned to chromosome 5 using fluorescence in situ hybridization analysis and PCR analysis of mouse/hamster hybrid cells.
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