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KMID : 0578319970070040521
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Molecules and Cells
1997 Volume.7 No. 4 p.521 ~ p.525
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Genetic Variation of the Apolipoprotein B Gene in Korean Patients with coronary Artery Disease
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Hong, Seung Ho
Lee, chung Choo/Kim, Jin Q
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Abstract
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In view of the clinical importance of apolipoprotein B (apo B) as a major risk factor for coronary artery disease (CAD), we investigated the two polymorphism was significantly higher in cases than the controls (P<0.05). Signal peptide polymorphism was also associated with levels of plasma cholesterol, triglyceride and low density lipoprotein-cholesterol. However, XbaⅠ polymorphism was not associated with plasma lipid levels. Therefore, our results suggest that signal peptide polymorphism of the apo B gene might be one of the factors in explaining an association in Korean CAD patients.
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KEYWORD
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