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KMID : 0578319970070060710
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Molecules and Cells
1997 Volume.7 No. 6 p.710 ~ p.714
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Colocalization of Dopamine D1 and D2 Receptor mRNAs In Rat Placenta
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Kim, Myeung Ok
Kim, jin Hyun/Choi, Wan Sung/Lee, Bong Hee/Cho, Gyeong Jae/Roh, Seing Man/Lee, Byung Ju
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Abstract
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Dopamine is present in the human placenta. The major function of dopamine is the inhibition of human placental lactogen (hPL) release from human trophoblastic cells. This effect is mediated by cAMP through dopamine D₂receptors. However, studies on the effects of cAMP in the control of hPL release have yielded conflicting results. The purpose of this study is to explore the distribution of dopamine receptors in the rat placenta. Dopamine D₁and D₂receptor mRNAs were colocalized in the rat placenta by in situ hybridization histochemistry using radiolabeled cRNA probes. Dopamine D₁and D₂receptor mRNAs were detected in large cells of the endometrium of the uterus on day 10 of gestation. On days 12-16 of gestation, hybridization signals were localized mainly in the spongiotrophoblast and giant cells of the junctional zone of the placenta. Within the development of the placenta, signals were moving from the junctional zone to the labyrinth zone. Pit-1 mRNA was detected in the placental lactotrophs and was also colocalized in geighboring placental sections. Our results clearly showed that dopamine D¹and D₂receptor mRNAs were coexpressed in the placental lactotrophs that express Pit-1 mRNA.
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