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KMID : 0578320060220010030
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Molecules and Cells
2006 Volume.22 No. 1 p.30 ~ p.35
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Munc18 Plays an Important Role in the Regulation of Glutamate Release during Female Puberty Onset
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Kim Byung U
Choi Jun-Gil
Ahn Kook-Hee
Jeong Jin-Kwon
Ha Chang-Man
Jeong Choon-Soo
Lee Byung-Ju
Lee Chae-Kwan
Kang Sung-Goo
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Abstract
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Munc18, a mammalian homolog of C. elegans Unc, is essential for neurotransmitter release. The aim of this study was to identify estrogen-dependent expression of Munc18-1 and its role in the regulation of glutamate release for puberty onset. Hypothalamic munc18-1 mRNA levels were significantly increased by estrogen treatment in ovariectomized, immature female rats. During pubertal development, the munc18-1 mRNA levels dramatically increased between the juvenile period and the anestrous phase of puberty. Intracerebroventricular administration of an antisense oligodeoxynucleotide against munc18-1 mRNA significantly decreased glutamate release and delayed the day of puberty onset. These results suggest that Munc18-1, expressed in an estrogen-dependent manner, plays an important role in the onset of female puberty via the regulation of glutamate release.
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KEYWORD
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Antisense Oligodeoxynucleotide, Estradiol, Pubertal Development, RNase Protection Assays
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