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KMID : 0578320060220010051
Molecules and Cells
2006 Volume.22 No. 1 p.51 ~ p.57
Haloperidol Induces Calcium Ion Influx Via L-Type Calcium Channels in Hippocampal HN33 Cells and Renders the Neurons More Susceptible to Oxidative Stress
Kim Hyeon-Soo

Sanatombi Yumkham
Choi Jang-Hyun
Kim Eung-Kyun
Ryu Sung-Ho
Suh Pan-Ghil
Kim Yong-Sik
Abstract
Haloperidol is a classical neuroleptic drug that is still in clinical use and can lead to abnormal motor activity following repeated administration. However, there is little knowledge of how it triggers neuronal impairment. In this study, we report that it induced calcium ion influx via L-type calcium channels and that the elevation of calcium ions induced by haloperidol appeared to render hippocampal cells more susceptible to oxidative stress. Indeed, the level of cytotoxic reactive oxygen species (ROS) and the expression of proapoptotic Bax increased in response to oxidative stress in haloperidol-treated cells, and these effects were inhibited by verapamil, a specific L-type calcium channel blocker, but not by the T-type calcium channel blocker, mibefradil. These findings indicate that haloperidol induces calcium ion influx via L-type calcium channels and that this calcium influx influences neuronal fate.
KEYWORD
Calcium, Haloperidol, Hippocampus, L-Type Calcium Channel, Oxidative Stress, Verapamil
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