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KMID : 0578320060220030308
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Molecules and Cells
2006 Volume.22 No. 3 p.308 ~ p.313
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The Chemokine SDF-1α Suppresses Fibronectin-mediated In Vitro Lymphocytes Adhesion
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Ji LiLi
Tao Wang Zheng
Sheng YuChen
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Abstract
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Stromal cell-derived factor (SDF-1) is a CXC chemokine that selectively activates the CXCR4 chemokine receptor. Fibronectin is an intracellular matrix component that binds integrin and mediates cell-matrix adhesion. Activation of the integrin receptor can occur in two ways: by ligand binding (outside-in signaling), and in response to intracellular events (inside-out signaling). In the current study we showed that SDF-1a inhibited adhesion of T lymphocyte Jurkat cells resulting from binding high concentrations of fibronectin as well as that of THP-1 monocytes. The effect of SDF-1a on fibronectin-mediated adhesion was partly reversed by the CXCR4 receptor antagonist T140. Our results suggest that an SDF-1/ CXCR4 signal pathway modulates fibronectin-mediated lymphocytes adhesion.
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KEYWORD
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Adhesion, Chemokine, Fibronectin, Lymphocytes, SDF-1α, T140
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