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KMID : 0578320060220030360
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Molecules and Cells
2006 Volume.22 No. 3 p.360 ~ p.363
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Formation of a New Solo-LTR of the Human Endogenous Retrovirus H Family in Human Chromosome 21
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Huh Jae-Won
Ha Hong-Seok
Kim Tae-Hong
Kim Heui-Soo
Kim Dae-Soo
Kim Wook
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Abstract
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Human endogenous retroviruses (HERVs) contribute to various kinds of genomic instability via rearrangement and retrotransposition events. In the present study the formation of a new human-specific solo-LTR belonging to the HERV-H family (AP001667; chromosome 21q21) was detected by a comparative analysis of human chromosome 21 and chimpanzee chromosome 22. The solo-LTR was formed as a result of an equal homologous recombination excision event. Several evolutionary processes have occurred at this locus during primate evolution, indicating that mammalian-wide interspersed repeat (MIR) and full-length HERV-H elements integrated into hominoid genomes after the divergence of Old World monkeys and hominoids, and that the solo-LTR element was created by recombination excision of the HERV-H only in the human genome.
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KEYWORD
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HERV-H Element, Solo-LTR, Recombination Excision, Retrotransposition
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