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KMID : 0578320070230020215
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Molecules and Cells
2007 Volume.23 No. 2 p.215 ~ p.219
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TTF-1 Expression in PACAP-expressing Retinal Ganglion Cells
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Son Young-June
Park Jeong-Woo
Lee Byung-Ju
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Abstract
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In mammals light input resets the central clock of the suprachiasmatic nucleus by inducing secretion of pituitary adenylate cyclase-activating polypeptide (PACAP) from retinal ganglion cells (RGCs). We previously showed that thyroid transcription factor 1 (TTF-1), a homeodomain-containing transcription factor, specifically regulates PACAP gene expression in the rat hypothalamus. In the present study we examined the expression of TTF-1 in PACAP-synthesizing retinal cells. Fluorescence in situ hybridization (FISH) showed that it is abundantly expressed in RGCs of the superior region of the retina, but in only a small subset of RGCs in the inferior region. Double FISH experiments revealed that TTF-1 is exclusively expressed in PACAP-producing RGCs. These results suggest that TTF-1 plays a regulatory role in PACAP-expressing retinal ganglion cells.
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KEYWORD
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Double Fluorescence In Situ Hybridization, Expression Pattern, Melanopsin, Retinal Ganglion Cells, Thyroid Transcription Factor 1 (TTF-1)
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