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KMID : 0578320080250010050
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Molecules and Cells
2008 Volume.25 No. 1 p.50 ~ p.54
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Human Vesicular Glutamate Transporters Functionally Complement EAT-4 in C. elegans
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Lee Duk-Gyu
Jung Sun-Ki
Ahnn Joo-Hong
Ha II-Ho
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Abstract
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The vesicular glutamate transporter (VGLUT) transports glutamate into pre-synaptic vesicles. Three isoforms of VGLUT have been identified in humans, but their functional differences remain largely unknown. EAT-4 is the only homologue of human VGLUT in C. elegans. Here we report that mutants of eat-4 exhibit hyperforaging behavior and that each of the isoforms of human VGLUT functionally rescues the defects in eat-4 worms.
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KEYWORD
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C. elegans, eat-4, Foraging, Pharyngeal Pumping, VGLUT
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