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KMID : 0578320080250010064
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Molecules and Cells
2008 Volume.25 No. 1 p.64 ~ p.69
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CD4+CD25+ Regulatory T Cells Selectively Diminish Systemic Autoreactivity in Arthritic K/BxN Mice
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Kang Sang-Mee
Jang Eun-Kyeong
Paik Doo-Jin
Jang Young-Ju
Youn Jee-Hee
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Abstract
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Although the arthritis symptoms observed in the K/BxN model have been shown to be dependent on the functions of T and B cells specific to the self antigen glucose-6-phosphate isomerase, less is known about the in vivo roles of CD4+CD25+ regulatory T (Treg) cells in the pathology of K/BxN mice. We determined the quantitative and functional characteristics of the Treg cells in K/BxN mice. These mice contained a higher percentage of Foxp3+ Treg cells among the CD4+ T cells than their BxN littermates. These Treg cells were anergic and efficiently suppressed the proliferation of naive CD4+ T cells and cytokine production by effector CD4+ T cells in vitro. Antibody-mediated depletion of CD25+ cells caused K/BxN mice to develop multi-organ inflammation and autoantibody production, while the symptoms of arthritis were not affected. These results demonstrate that despite the inability of the Treg cells to suppress arthritis development, they play a critical role protecting the arthritic mice from systemic expansion of autoimmunity.
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KEYWORD
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Autoimmunity, K/BxN Model, Regulatory TCells, Rheumatoid Arthritis
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