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KMID : 0578320080250020317
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Molecules and Cells
2008 Volume.25 No. 2 p.317 ~ p.322
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Stage-specific Expression of Ankyrin and SOCS Box Protein-4 (Asb-4) during Spermatogenesis
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Kim Soo-Kyoung
Lee Dong-Ryul
Kim Kye-Seong
Rhim Si-Youn
Lee Man-Ryul
Kim Jong-Soo
Kim Hyung-Jun
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Abstract
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Members of the large family of Asb proteins are ubiquitously expressed in mammalian tissues; however, the roles of individual Asb and their function in the developmental testes have not been reported. In this report, we isolated a murine Asb4 from mouse testis. Northern blot analysis revealed that mAsb-4 was expressed only in testes and produced in a stage-specific manner during spermatogenesis. It was expressed in murine testes beginning in the fourth week after birth and extending into adulthood. Pachytene spermatocytes had the highest level of expression. Interestingly, the human homologue of mAsb-4, ASB-4 (hASB-4) was also expressed in human testis. These results suggest that ASB-4 plays pivotal roles in mammalian testis development and spermatogenesis.
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KEYWORD
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Ankyrin-Repeat, Asb-4, SOCS Box, Spermatogenesis
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