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KMID : 0578320080250030397
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Molecules and Cells
2008 Volume.25 No. 3 p.397 ~ p.406
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Kinetic Analysis of the MAPK and PI3K/Akt Signaling Pathways
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Suresh Babu CV
Sheikh Md. Enayetul Babar
Song Eun-Joo
Oh Eul-Sik
Yoo Young-Sook
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Abstract
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Computational modeling of signal transduction is currently attracting much attention as it can promote the understanding of complex signal transduction mechanisms. Although several mathematical models have been used to examine signaling pathways, little attention has been given to crosstalk mechanisms. In this study, an attempt was made to develop a computational model for the pathways involving growth-factor-mediated mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3’-kinase/protein kinase B (PI3K/Akt). In addition, the dynamics of the protein activities were analyzed based on a set of kinetic data. The simulation approach integrates the information on several levels and predicts systems behavior. The in-silico analysis conducted revealed that the Raf and Akt pathways act independently.
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KEYWORD
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Biochemical Pathway, Computational Modeling, MAPK, PI3K/Akt, Signal Transduction, Systems Biology
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