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KMID : 0578320080250040531
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Molecules and Cells
2008 Volume.25 No. 4 p.531 ~ p.537
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Curcumin Alleviates Dystrophic Muscle Pathology in mdx Mice
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Pan Ying
Chen Chen
Shen Yue
Zhu Chun-Hua
Wang Gang
Wang Xiao-Chun
Chen Hua-Qun
Zhu Min-Sheng
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Abstract
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Abnormal activation of nuclear factor kappa B (NF-kappaB) probably plays an important role in the pathogenesis of Duchenne’s muscular dystrophy (DMD). In this report, we evaluated the efficacy of curcumin, a potent NF-kappaB inhibitor, in mdx mice, a mouse model of DMD. We found that it improved sarcolemmic integrity and enhanced muscle strength after intraperitoneal (i.p.) injection. Histological analysis revealed that the structural defects of myofibrils were reduced, and biochemical analysis showed that creatine kinase (CK) activity was decreased. We also found that levels of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and inducible nitric oxide synthase (iNOS) in the mdx mice were decreased by curcumin administration. EMSA analysis showed that NF-kappaB activity was also inhibited. We thus conclude that curcumin is effective in the therapy of muscular dystrophy in mdx mice, and that the mechanism may involve inhibition of NF-kappaB activity. Since curcumin is a non-toxic compound derived from plants, we propose that it may be useful for DMD therapy.
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KEYWORD
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Creatine Kinase Activity, Curcumin, Interleukin-1beta, i.p. Injection, mdx Mice, Muscular Dystrophy, NF-κB, Tumor Necrosis Factor alpha
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