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KMID : 0578320090270050571
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Molecules and Cells
2009 Volume.27 No. 5 p.571 ~ p.575
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ATG5 expression induced by MDMA (ecstasy), interferes with neuronal differentiation of neuroblastoma cells
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Chae Myoung-Hee
Rhee Gyu-Seek
Jang Ik-Soon
Kim Kwang-Soo
Lee Ji-Hae
Lee Seung-Yeul
Kim Min-Jung
Yang Jun-Young
Park Jun-Soo
Lee Seung-Hoon
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Abstract
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The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.
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KEYWORD
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Atg5, autophagy, MDMA, neuron, PC12, SH-SY5Y
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