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KMID : 0578320090280010001
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Molecules and Cells
2009 Volume.28 No. 1 p.1 ~ p.5
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Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis
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Ha Chang-Hoon
Jin Zheng-Gen
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Abstract
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Vascular endothelial growth factor (VEGF) is essential for many angiogenic processes both in normal and pathological conditions. However, the signaling pathways involved in VEGF-induced angiogenesis are incompletely understood. The protein kinase D1 (PKD1), a newly described calcium/calmodulin-dependent serine/threonine kinase, has been implicated in cell migration, proliferation and membrane trafficking. Increasing evidence suggests critical roles for PKD1-mediated signaling pathways in endothelial cells, particularly in the regulation of VEGF-induced angiogenesis. Recent studies show that class IIa histone deacetylases (HDACs) are PKD1 substrates and VEGF signal-responsive repressors of myocyte enhancer factor-2 (MEF2) transcriptional activation in endothelial cells. This review provides a guide to PKD1 signaling pathways and the direct downstream targets of PKD1 in VEGF signaling, and suggests important functions of PKD1 in angiogenesis.
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KEYWORD
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angiogenesis, CAMK, endothelial cells, HDAC, MEF2, migration, PKC, PKD, VEGF
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