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KMID : 0578320090280010007
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Molecules and Cells
2009 Volume.28 No. 1 p.7 ~ p.12
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Biology of glioma cancer stem cells
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Park Deric M.
Rich Jeremy N.
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Abstract
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Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for in vitro and in vivo growth, a property intimately linked to the cell’s differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the so-called glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.
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KEYWORD
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brain tumor, cancer stem cell, glioma, glioblastoma
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