|
KMID : 0578320090280060583
|
|
Molecules and Cells
2009 Volume.28 No. 6 p.583 ~ p.588
|
|
|
Peroxiredoxin 6 promotes lung cancer cell invasion by inducing urokinase-type plasminogen activator via p38 kinase, phosphoinositide 3-kinase, and Akt
|
|
Lee Seung-Bum
Ho Jin-Nyoung
Yoon Sung-Hwan
Kang Ga-Young
Hwang Sang-Gu
Um Hong-Duck
|
|
|
Abstract
|
|
|
|
The peroxiredoxin family of peroxidase has six mammalian members (Prx 1?6). Considering their frequent up-regulation in cancer cells, Prxs may contribute to cancer cells’ survival in face of oxidative stress. Here, we show that Prx 6 promotes the invasiveness of lung cancer cells, accompanied by an increase in the activity of phosphoinositide 3-kinase (PI3K), the phosphorylation of p38 kinase and Akt, and the protein levels of uPA. Functional studies reveal that these components support Prx 6-induced invasion in the sequence p38 kinase/PI3K, Akt, and uPA. The findings provide a new understanding of the action of Prx 6 in cancer.
|
|
|
KEYWORD
|
|
|
cancer, cell signaling, invasion, peroxiredoxin 6
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|