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KMID : 0578320100290030229
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Molecules and Cells
2010 Volume.29 No. 3 p.229 ~ p.232
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MARCH-I: a New Regulator of Dendritic Cell Function
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Satoshi Ishido
Yohei Matsuki
Eiji Goto
Mizuho Kajikawa
Mari Ohmura-Hoshino
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Abstract
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We and other groups have demonstrated that the expres-sion level of MHC class II (MHC II) is regulated through ubiquitination of the MHC II β chain. We also reported that MARCH-I, an E3 ubiquitin ligase, is critical for this process. At present, however, the importance of MARCH-I-mediated MHC II regulation in vivo is still unknown. In this review, we will summarize recent advances in our understanding of MARCH-I-mediated MHC II ubiquitination, and discuss how we can overcome the difficulties inherent in these studies.
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KEYWORD
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antigen presentation, E3 ubiquitin ligase, MHC class II
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