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KMID : 0578320100290030233
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Molecules and Cells
2010 Volume.29 No. 3 p.233 ~ p.237
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δ-Catenin Affects the Localization and Stability of p120-Catenin by Competitively Interacting with E-Cadherin
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Yang Il-Hwan
Chang Oc-Kyoung
Qun Lu
Kim Kwon-Seop
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Abstract
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E-cadherin is a member of the cadherin family of Ca2+-dependent cell-cell adhesion molecules. p120-Catenin and δ-catenin are known to bind to similar juxtamembrane regions of E-cadherin, and p120-catenin is known to stabilize E-cadherin. However, the function of competition between p120-catenin and δ-catenin for E-cadherin has not been fully explained. In this report, we show that cells overexpressing δ-catenin contain less p120-catenin than control cells at the cell-cell interface and that this causes the re-localization of p120-catenin from the plasma membrane to the cytosol. We show that successful binding by one to E-cadherin adversely affects the stability of the other.
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KEYWORD
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δ-catenin, adherens junction, E-cadherin, p120-catenin, protein stability
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