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KMID : 0578320100290030277
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Molecules and Cells
2010 Volume.29 No. 3 p.277 ~ p.282
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Increased Fat Due to Estrogen Deficiency Induces Bone Loss by Elevating Monocyte Chemoattractant Protein-1 (MCP-1) Production
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Kim Youn-Young
Kim Song-Hee
Oh So-Ra
Sul Ok-Joo
Lee Hye-Young
Kim Hyun-Ju
Kim Shin-Yoon
Choi Hye-Seon
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Abstract
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Ovariectomy (OVX)-induced estrogen withdrawal resulted in both bone loss and an increase in fat. We observed elevated osteoclast (OC) formation by bone marrow-derived macrophages treated with medium conditioned by fats from OVX mice, but not from sham-operated mice. Fats from OVX mice expressed and secreted higher levels of monocyte chemoattractant protein-1 (MCP-1) than those from sham-operated mice. Increased fat resulting from estrogen deficiency is thus responsible for bone loss due to enhanced OC formation, which is, at least partly, a consequence of elevated MCP-1 production.
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KEYWORD
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bone loss, fat, MCP-1, osteoclast formation, ovariectomy
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