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KMID : 0578320100290040311
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Molecules and Cells
2010 Volume.29 No. 4 p.311 ~ p.325
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Regulation of Actin Cytoskeleton Dynamics in Cells
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Lee Sung-Haeng
Roberto Dominguez
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Abstract
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The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities, and malfunction of cytoskeletal proteins results in various human diseases. The transition between two forms of actin, monomeric or G-actin and filamentous or F-actin, is tightly regulated in time and space by a large number of signaling, scaffolding and actin-binding proteins (ABPs). New ABPs are constantly being discovered in the post-genomic era. Most of these proteins are modular, integrating actin binding, protein-protein interaction, membrane-binding, and signaling domains. In response to extracellular signals, often mediated by Rho family GTPases, ABPs control different steps of actin cytoskele-ton assembly, including filament nucleation, elongation, severing, capping, and depolymerization. This review summarizes structure-function relationships among ABPs in the regulation of actin cytoskeleton assembly.
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KEYWORD
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actin-binding protein, actin cytoskeleton, BAR protein, F-actin, filament cross-linking, filament nucleation and elongation, G-actin, Rho-GTPase, WH2
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